Basic Information
VIS ID
TVIS44006652
Fusion event
HTLV-1-LCT integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q21.3
Reference genome
GRCh37/hg19
Start
136585834/135828264 (Hg38)
End
136585834/135828264 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA2S ; FRA2F
Target gene
LCT
miRNAs that regulate target gene
hsa-mir-671-5p
Nearest miRNA
hsa-mir-128-1/Upstream/162786; hsa-mir-10b/Downstream/4758362;
Nearest TSS
ENST00000437798/Upstream/8073; ENST00000444406/Downstream/8916;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/85690, chr2-CpG: 83/Downstream/47529
Upstream sequence
caggtgcgtgccaccacacccatctaatttttgtatttttagtagagatgggtttttgccatgttggccaggatggtcttaatctcttgatctcatgatc
Downstream sequence
cacccacctcggcctcccaaagtgctgggattacaggcatgagccactgtgcctagccAAACTTGGCCTTTAAAGGGATAATTCCTCAGGTAAACCATCC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate