Basic Information
VIS ID
TVIS44006680
Fusion event
HTLV-1-DRD3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
q13.31
Reference genome
GRCh37/hg19
Start
113875266/114156419 (Hg38)
End
113875266/114156419 (Hg38)
Orient
-
Location type
Intronic
Target gene
DRD3
miRNAs that regulate target gene
hsa-mir-26b-5p
Nearest miRNA
hsa-let-7g/Upstream/561477; hsa-mir-12124/Downstream/160056;
Nearest TSS
ENST00000440867/Upstream/73650; ENST00000481773/Downstream/22279;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/3453, chr3-CpG: 82/Downstream/194459
Upstream sequence
TAAAAACCAAACCATTAAAGCACCAAATCGTCTCGACATGGTGATCTCTTCTTGACAGCATCTTTCTCCTGGAATCTTGTGTTCTGTTTGACTCCTTTCT
Downstream sequence
CTTCCTAATCTTTCATATTCAAGAGGTTGGTGTTTACAGACCTTTTGCCGTTTTTTTTTTCAAAATTTCCCCTACTTTTCCTTTCTTGTTTCCTCCTATT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate