Basic Information
VIS ID
TVIS44006684
Fusion event
HTLV-1-chr3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
q29
Reference genome
GRCh37/hg19
Start
193787911/194070122 (Hg38)
End
193787911/194070122 (Hg38)
Orient
-
Location type
Intronic
Target gene
LINC02028 ; LOC102724877
Nearest miRNA
hsa-let-7g/Upstream/4240113; hsa-mir-3137/Downstream/1064384;
Nearest TSS
ENST00000440867/Upstream/19; ENST00000615240/Downstream/117;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/11593, chr3-CpG: 87/Downstream/570
Nearby gene
HES1(+66020) ;
Upstream sequence
AGCAGCTGCCATAAGCAGAGTTCTCAAATAATCATTTGTGTGGAAATCAAAAAGGAGGGCAACACAGTCTCTGCCCTCAGGAAACTCCGGAAGGGAGGAG
Downstream sequence
AGGACAGGTAGGCCATGAGTTACAGGGGGCCACAAACGTCATAAACAGGCGTTTGTCAAAGGCCGCCGGAGAACCGGGAAGCAATGATTGGGCAAATCTG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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