Basic Information
VIS ID
TVIS44006694
Fusion event
HTLV-1-TMPRSS11B integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q13.2
Reference genome
GRCh37/hg19
Start
69100245/68234527 (Hg38)
End
69100245/68234527 (Hg38)
Orient
-
Location type
Exonic
Target gene
TMPRSS11B
miRNAs that regulate target gene
hsa-mir-6830-3p ; hsa-mir-6809-3p ; hsa-mir-4659b-3p ; hsa-mir-4659a-3p ; hsa-mir-6875-3p ; hsa-mir-6833-3p ; hsa-mir-4768-5p ; hsa-mir-6873-3p ; hsa-mir-942-5p ; hsa-mir-6845-3p
Nearest miRNA
hsa-mir-12113/Upstream/1957599; hsa-mir-1243/Downstream/8339041;
Nearest TSS
ENST00000502981/Upstream/4849; ENST00000510647/Downstream/11164;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/51808, chr4-CpG: 52/Downstream/115059
Upstream sequence
TATGTAATAGAAAATAATGGAAATAAGTCAAATACCCATGAGTTTAATGGAAGCAGGAACTGCATTCCAGGATGCCATGTTGTTTTTCAACATCTGATGT
Downstream sequence
AATTTAGCCTTGATTTTAGTCCTCATGCTAACTCCTTCTGCTGGAGGAAACTTGAATTTCAGCTGTAACTGCACATTTGAACCATTGGCATTAGGCCTAG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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