Proximate region of VIS (GRCh38)VISEnhancerEnhancer/PromoterPromoterGene9842894998470367986586299849636498509935985144629852556098508443985117409852597298527836985291889853096798494682984952889849407698494471985056599850599898496197984964769853763798537818984955709849571998543789
Basic Information
VIS ID
TVIS44006698
Fusion event
HTLV-1-TSPAN5 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q23
Reference genome
GRCh37/hg19
Start
99464940/98543789 (Hg38)
End
99464940/98543789 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA4E
Target gene
TSPAN5
miRNAs that regulate target gene
hsa-mir-335-5p
Nearest miRNA
hsa-mir-12113/Upstream/11243206; hsa-mir-1243/Downstream/453598;
Nearest TSS
ENST00000502981/Upstream/47425; ENST00000569927/Downstream/16444;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/281741, chr4-CpG: 97/Downstream/114202
Upstream sequence
gattacaggtgtgagccactgcacccagccTACTTTAGAATTTTTAAATGTCTTTAGGGAATTTTCTAATTTTCCCCCAAATAATGCATACCTTGAGACT
Downstream sequence
ACCTGAATCCATACCTTTTTCTATATGTGAACTTCACGACATTTGATTTATCCATCCTATACAGTTATAGAATATTAGATCACAATATTGGGCTTAAAAA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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