Basic Information
VIS ID
TVIS44006704
Fusion event
HTLV-1-LPCAT1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
p15.33
Reference genome
GRCh37/hg19
Start
1521684/1521569 (Hg38)
End
1521684/1521569 (Hg38)
Orient
+
Location type
Intronic
Target gene
LPCAT1
miRNAs that regulate target gene
hsa-mir-193b-3p ; hsa-mir-335-5p ; hsa-mir-340-5p ; hsa-mir-375 ; hsa-mir-26b-5p ; hsa-mir-186-5p ; hsa-mir-205-5p ; hsa-mir-542-3p ; hsa-mir-4504 ; hsa-mir-7974 ; hsa-mir-6077 ; hsa-mir-4632-3p ; hsa-mir-4707-3p ; hsa-mir-6884-5p ; hsa-mir-485-5p ; hsa-mir-4783-3p ; hsa-mir-7108-3p ; hsa-mir-30e-5p ; hsa-mir-30c-5p ; hsa-mir-30d-5p ; hsa-mir-30b-5p ; hsa-mir-30a-5p ; hsa-mir-27b-3p ; hsa-mir-27a-3p ; hsa-mir-193a-3p ; hsa-mir-181d-5p ; hsa-mir-181b-5p ; hsa-mir-181c-5p ; hsa-mir-181a-5p
Nearest miRNA
hsa-mir-4457/Upstream/10713; hsa-mir-10397/Downstream/187216;
Nearest TSS
ENST00000502646/Upstream/26641; ENST00000605200/Downstream/2171;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/26397, chr5-CpG: 148/Downstream/1341
Upstream sequence
CTCTGTGGAAACTTTACAAGAATATATCACATCAAAGTAAAAGCTTTGCAAAGCAATGCTTGGTGAAAAGCAAAATGTTTCTGCAGAGAACTTTGAGAAC
Downstream sequence
GTTTACAAACTAAACCCTTGAGCCACACATTGCAGACATCCAGCAGAAACGACTGGATGTACAAACACACCTAATTCCTCAGATGGAACCTCTGAAGTGG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate