Basic Information
VIS ID
TVIS44006708
Fusion event
HTLV-1-ARL15 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q11.2
Reference genome
GRCh37/hg19
Start
53290658/53994828 (Hg38)
End
53290658/53994828 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA5H
Target gene
ARL15
miRNAs that regulate target gene
hsa-let-7b-5p ; hsa-mir-744-5p ; hsa-mir-155-5p ; hsa-mir-142-3p ; hsa-mir-7-5p ; hsa-mir-222-5p ; hsa-mir-3177-5p ; hsa-mir-7110-3p ; hsa-mir-4797-3p ; hsa-mir-4264 ; hsa-mir-936 ; hsa-mir-648 ; hsa-mir-199b-3p ; hsa-mir-199a-3p ; hsa-mir-3129-5p ; hsa-mir-6873-3p ; hsa-mir-6817-3p
Nearest miRNA
hsa-mir-10397/Upstream/43229; hsa-mir-103a-1/Downstream/1175704;
Nearest TSS
ENST00000502646/Upstream/113777; ENST00000512618/Downstream/315587;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/433788, chr5-CpG: 59/Downstream/315274
Upstream sequence
CCAGCTGCCTTGttttaaaattttttttaaattattttGAAAGTCCTATGCCATTAATATTAATATTAGAGCCATTTAAATGAAAACACACAAACCTCAA
Downstream sequence
ATCAACACTTATTTTTCTTTCtttttatatggacaggggtctcactatgttgctgaggctggtctcaaactcctgtcttcaagcaatcctcccacctcag
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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