Basic Information
VIS ID
TVIS44006717
Fusion event
HTLV-1-HIVEP1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
p24.1
Reference genome
GRCh37/hg19
Start
12047831/12047598 (Hg38)
End
12047831/12047598 (Hg38)
Orient
+
Location type
Intronic
Target gene
HIVEP1
miRNAs that regulate target gene
hsa-mir-221-3p ; hsa-mir-98-5p ; hsa-mir-32-5p ; hsa-mir-23a-3p ; hsa-mir-363-3p ; hsa-mir-25-3p ; hsa-mir-92a-3p ; hsa-mir-367-3p ; hsa-mir-433-3p ; hsa-mir-92b-3p ; hsa-mir-1206 ; hsa-mir-7154-5p ; hsa-mir-595 ; hsa-mir-410-3p ; hsa-mir-3613-3p ; hsa-mir-190a-3p ; hsa-mir-3163 ; hsa-mir-548e-5p
Nearest miRNA
hsa-mir-3691/Upstream/1607804; hsa-mir-10398/Downstream/4093958;
Nearest TSS
ENST00000381078/Upstream/32011; ENST00000399469/Downstream/78148;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/34764, chr6-CpG: 44/Downstream/702047
Nearest cancer related gene
HIVEP1(TSG, No orient, 0)
Upstream sequence
TGCTGGGAGGGGAGACAGGTTCATGGTAGCCCTGGGCAGCCTAGGTCACATCGCGGGTCTCACAGCCACTGGAGCAGAGGTGCTACTCAGAAGCAGGTGT
Downstream sequence
TCTGCCACAAACACATCTTCTTTCCGTCCTGTCACACTGCTGATTGCTGTTAAGAGTTTGGCCTTTCCCTCACTCTGCTTTTGGAGTGGGATTGGCTGAG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate