Basic Information
VIS ID
TVIS44006723
Fusion event
HTLV-1-UST integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
q25.1
Reference genome
GRCh37/hg19
Start
149113156/148792020 (Hg38)
End
149113156/148792020 (Hg38)
Orient
+
Location type
Intronic
Target gene
UST
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-335-5p ; hsa-mir-98-5p ; hsa-mir-1296-5p ; hsa-mir-6780a-5p ; hsa-mir-6779-5p ; hsa-mir-3689c ; hsa-mir-3689b-3p ; hsa-mir-3689a-3p ; hsa-mir-30b-3p ; hsa-mir-1273h-5p ; hsa-mir-3978 ; hsa-mir-6778-5p ; hsa-mir-1233-5p ; hsa-mir-486-3p ; hsa-mir-6799-5p ; hsa-mir-6883-5p ; hsa-mir-6785-5p ; hsa-mir-4728-5p ; hsa-mir-149-3p ; hsa-mir-7106-5p ; hsa-mir-449b-5p ; hsa-mir-449a ; hsa-mir-34c-5p ; hsa-mir-34a-5p ; hsa-mir-6851-5p ; hsa-mir-3689d ; hsa-mir-6134 ; hsa-mir-423-5p ; hsa-mir-3184-5p ; hsa-mir-6743-5p ; hsa-mir-194-3p ; hsa-mir-4688 ; hsa-mir-5692b ; hsa-mir-5692c ; hsa-mir-641 ; hsa-mir-3617-5p ; hsa-mir-5692a ; hsa-mir-154-5p ; hsa-mir-374a-5p ; hsa-mir-369-3p ; hsa-mir-374b-5p ; hsa-mir-149-5p ; hsa-mir-660-3p ; hsa-mir-5196-3p ; hsa-mir-5193 ; hsa-mir-6765-3p
Nearest miRNA
hsa-mir-10398/Upstream/8108137; hsa-mir-1202/Downstream/2310655;
Nearest TSS
ENST00000381078/Upstream/44692; ENST00000473631/Downstream/161887;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/43381, chr6-CpG: 97/Downstream/85203
Upstream sequence
TCTAAGCTTGCACACTTACTTTAGGAAACTCAAATGGAAACCCCACTCTCAAATAGTCTAATCTAATTACCTTTGGTTCTGGAAAGCAGCATCCAAGAGG
Downstream sequence
AAAGAGATTGTAAAATCCTCAGAGGAAGCGGGGAAAGTGGGTCTGAGAAGAGGGGACGAGAGCCTAGGAGTCAGCAGGTAGCTCAAAGGATGAGATGGAT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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