Basic Information
VIS ID
TVIS44006733
Fusion event
HTLV-1-ZNF680 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q11.21
Reference genome
GRCh37/hg19
Start
64019324/64558946 (Hg38)
End
64019324/64558946 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA7J
Target gene
ZNF680
miRNAs that regulate target gene
hsa-mir-6807-5p ; hsa-mir-548aw ; hsa-mir-19b-3p ; hsa-mir-19a-3p ; hsa-mir-1468-3p ; hsa-mir-548x-5p ; hsa-mir-548g-5p ; hsa-mir-548f-5p ; hsa-mir-548aj-5p ; hsa-mir-3682-3p ; hsa-mir-3145-3p ; hsa-mir-3163 ; hsa-mir-4676-5p ; hsa-mir-575 ; hsa-mir-1252-3p ; hsa-mir-3662 ; hsa-mir-5047 ; hsa-mir-1301-3p ; hsa-mir-7156-3p ; hsa-mir-107 ; hsa-mir-103a-3p ; hsa-mir-4766-5p ; hsa-mir-7157-5p ; hsa-mir-4310 ; hsa-mir-6826-5p ; hsa-mir-4519 ; hsa-mir-4724-5p ; hsa-mir-548e-5p ; hsa-mir-26b-5p ; hsa-mir-26a-5p
Nearest miRNA
hsa-mir-1183/Upstream/937777; hsa-mir-10399/Downstream/120118;
Nearest TSS
ENST00000635602/Upstream/14727; ENST00000360117/Downstream/4076;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/94583, chr7-CpG: 87/Downstream/10578
Upstream sequence
agaaacacaagtcgcaataggatctgtgtcctgtgttttttccaaagaatgttttgggaacttcagtatttaaagaggaaagagcaagtgggaggggaag
Downstream sequence
aaaaaaggccgggtgggggaaacaagagggagtgtaggtgatgaggctattggctacattcccatgaggctctgattagcactcagtgaatctatatttt
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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