Basic Information
VIS ID
TVIS44006734
Fusion event
HTLV-1-GNAI1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q21.11
Reference genome
GRCh37/hg19
Start
79792217/80162901 (Hg38)
End
79792217/80162901 (Hg38)
Orient
+
Location type
Intronic
Target gene
GNAI1
miRNAs that regulate target gene
hsa-mir-186-5p ; hsa-mir-1-3p ; hsa-mir-320a ; hsa-mir-320c ; hsa-mir-320d ; hsa-mir-9-3p ; hsa-mir-4719 ; hsa-mir-8485 ; hsa-mir-676-5p ; hsa-mir-466 ; hsa-mir-4672 ; hsa-mir-3941 ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-409-5p
Nearest miRNA
hsa-mir-10525/Upstream/4247632; hsa-mir-10399/Downstream/12041114;
Nearest TSS
ENST00000635602/Upstream/27146; ENST00000447650/Downstream/24158;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/27328, chr7-CpG: 59/Downstream/756089
Upstream sequence
TTTTGAGACATCCTGTGGGAAGAGATTTAAGAGAGTTGAGGTGGCCTTCAGTGAAGAGAAACCGCAAGGAAGAATGGAAGTGTGTGGGTAATATTGATAG
Downstream sequence
GTTTCTGCTCTGCATTGTTTGATGTTAATCTTATTCTTGTCTTCCCACAAAATCTTTAAAGTGTTTGCTTTAAAAAATAATTTGTAAAACTGGGTTTGTT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate