Basic Information
VIS ID
TVIS44006735
Fusion event
HTLV-1-ZNF804B integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q21.13
Reference genome
GRCh37/hg19
Start
88407234/88777920 (Hg38)
End
88407234/88777920 (Hg38)
Orient
+
Location type
Intronic
Target gene
ZNF804B
miRNAs that regulate target gene
hsa-mir-335-5p
Nearest miRNA
hsa-mir-10525/Upstream/12862651; hsa-mir-10399/Downstream/3426095;
Nearest TSS
ENST00000635602/Upstream/18552; ENST00000611114/Downstream/17801;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/17951, chr7-CpG: 98/Downstream/1340658
Upstream sequence
atgggtgacagagtgagactccatctaaaaaaaaaaaaaaaaaaaaaTTGCAGAAACTGAGAGGAAGTGGCATTAACTAATGAAGGAAATTATTTTCTGA
Downstream sequence
ATATATATGTATATATCTGTTATACAGAAATCTAAAGAATGGGTACAAATATTTATATTCAACTCACACCTCAtgtattagtttcccactgctactgtaa
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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