Basic Information
VIS ID
TVIS44006745
Fusion event
HTLV-1-ADAM9 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
p11.22
Reference genome
GRCh37/hg19
Start
38946307/39088788 (Hg38)
End
38946307/39088788 (Hg38)
Orient
-
Location type
Intronic
Target gene
ADAM9
miRNAs that regulate target gene
hsa-mir-373-3p ; hsa-mir-126-3p ; hsa-mir-126-5p ; hsa-mir-26b-5p ; hsa-mir-23a-3p ; hsa-mir-125a-5p ; hsa-mir-1252-3p ; hsa-mir-3646 ; hsa-mir-3941 ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-8485 ; hsa-mir-4520-5p ; hsa-mir-4799-5p ; hsa-mir-4666a-5p ; hsa-mir-633 ; hsa-mir-7114-3p ; hsa-mir-1180-5p ; hsa-mir-1228-3p ; hsa-mir-4495 ; hsa-mir-451b ; hsa-mir-30e-5p ; hsa-mir-30b-5p ; hsa-mir-30d-5p ; hsa-mir-30a-5p ; hsa-mir-30c-5p ; hsa-mir-543 ; hsa-mir-33a-5p ; hsa-mir-140-5p
Nearest miRNA
hsa-mir-124-1/Upstream/9131440; hsa-mir-10400/Downstream/2182260;
Nearest TSS
ENST00000518652/Upstream/12900; ENST00000463437/Downstream/997;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/91191, chr8-CpG: 47/Downstream/18706
Nearest cancer related gene
ADAM9(OG, No orient, 0)
Upstream sequence
ATTTGTAAAAGTTCTAATGAAACTTAAAATCTAGAAGGCGTaaaaataagattgataaattcaactatacaaaaataataaacttttccgtggagaaaag
Downstream sequence
catagtgccataggttaaaatggggaaaatatttccaacttgtatcatggacaaagctaatctctctaatatataaagaacttttagaaattaagaagaa
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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