Proximate region of VIS (GRCh38)VISEnhancerEnhancer/PromoterPromoterGene9320653293058688930851389309621893113283931214899313428893125498931356459309094493100394931106019311705293118585931218299310877993110200931074529310872593094939930955299308351293083884930826199308283993132610
Basic Information
VIS ID
TVIS44006752
Fusion event
HTLV-1-NINJ1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
q22.31
Reference genome
GRCh37/hg19
Start
95894892/93132610 (Hg38)
End
95894892/93132610 (Hg38)
Orient
+
Location type
Intronic
Target gene
NINJ1
miRNAs that regulate target gene
hsa-mir-107 ; hsa-mir-3658 ; hsa-mir-3653-3p ; hsa-mir-6499-3p ; hsa-mir-3613-3p ; hsa-mir-5700 ; hsa-mir-6507-5p ; hsa-mir-6807-5p ; hsa-mir-7151-3p ; hsa-mir-5095 ; hsa-mir-550a-5p ; hsa-mir-550a-3-5p ; hsa-mir-1271-3p ; hsa-mir-6759-3p ; hsa-mir-6504-3p ; hsa-mir-4438 ; hsa-mir-335-3p ; hsa-mir-452-3p ; hsa-mir-627-3p ; hsa-mir-4704-3p ; hsa-mir-587 ; hsa-mir-3671 ; hsa-mir-6884-3p ; hsa-mir-5094 ; hsa-mir-3529-3p ; hsa-mir-1298-5p ; hsa-mir-7154-5p ; hsa-mir-433-3p ; hsa-mir-6853-3p ; hsa-mir-5701 ; hsa-mir-4417 ; hsa-mir-1206 ; hsa-mir-27a-5p
Nearest miRNA
hsa-mir-101-2/Upstream/604552; hsa-let-7a-1/Downstream/462231;
Nearest TSS
ENST00000422679/Upstream/6420; ENST00000366188/Downstream/1609;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/35760, chr9-CpG: 103/Downstream/1115
Nearest cancer related gene
NINJ1(TSG, No orient, 0)
Upstream sequence
ctgccctccagggctcagagccaatgtccccacctccacagaaagccttccctgaccaccatgccccgccccccacgatgggctcccagcccccagggaa
Downstream sequence
ccccctgctttgccctggcctctcctgccctgtctgggctgggctgctctccaaccgcggcttggtggggcggggctgtgtctctctccctctggtgccc
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate