Basic Information
VIS ID
TVIS44006753
Fusion event
HTLV-1-FAM120AOS integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
q22.31
Reference genome
GRCh37/hg19
Start
96209116/93446834 (Hg38)
End
96209116/93446834 (Hg38)
Orient
+
Location type
UTR3
Target gene
FAM120AOS
miRNAs that regulate target gene
hsa-mir-192-5p ; hsa-mir-190a-3p ; hsa-mir-5011-5p ; hsa-mir-526b-5p ; hsa-mir-1273f ; hsa-mir-4708-5p ; hsa-mir-6088 ; hsa-mir-4770 ; hsa-mir-143-3p ; hsa-mir-5584-3p ; hsa-mir-148a-5p ; hsa-mir-548t-5p ; hsa-mir-548az-5p ; hsa-mir-548n ; hsa-mir-5010-3p ; hsa-mir-2113 ; hsa-mir-4775 ; hsa-mir-6832-5p ; hsa-mir-4524a-3p ; hsa-mir-4735-5p ; hsa-mir-4524b-3p ; hsa-mir-938 ; hsa-mir-129-2-3p ; hsa-mir-129-1-3p ; hsa-mir-6779-3p ; hsa-mir-4687-5p ; hsa-mir-3123 ; hsa-mir-888-5p ; hsa-mir-1277-5p ; hsa-mir-106a-3p ; hsa-mir-4284 ; hsa-mir-4634 ; hsa-mir-122-5p ; hsa-mir-504-3p ; hsa-mir-4772-3p ; hsa-mir-4638-5p ; hsa-mir-1307-3p ; hsa-mir-1304-3p ; hsa-mir-6741-3p ; hsa-mir-6890-3p ; hsa-mir-1306-5p ; hsa-mir-652-3p ; hsa-mir-454-3p ; hsa-mir-4295 ; hsa-mir-3666 ; hsa-mir-301b-3p ; hsa-mir-301a-3p ; hsa-mir-130b-3p ; hsa-mir-130a-3p
Nearest miRNA
hsa-mir-101-2/Upstream/918776; hsa-let-7a-1/Downstream/148007;
Nearest TSS
ENST00000422679/Upstream/9713; ENST00000375389/Downstream/4149;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/100124, chr9-CpG: 166/Downstream/4224
Upstream sequence
aggccctccatgagaacaactcttctcttccacatagatatttttgcatcagcccaaagctatttggacacaagtttggtgaacacggtaagAAAAAAAC
Downstream sequence
AAACCAAGCAACAAAAACAAAAAGCAGGCAGTGCTGTGTTAGACTGAAAGTAAAAGATAAAAACTCTAAGAACCTATGAAGCGCCAGGGCAGTGCTGGTT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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