Basic Information
VIS ID
TVIS44006754
Fusion event
HTLV-1-STX17 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
q31.1
Reference genome
GRCh37/hg19
Start
102710619/99948337 (Hg38)
End
102710619/99948337 (Hg38)
Orient
-
Location type
Intronic
Target gene
STX17
miRNAs that regulate target gene
hsa-mir-30b-5p ; hsa-mir-5089-5p ; hsa-mir-6811-5p ; hsa-mir-6511b-5p ; hsa-mir-5589-5p ; hsa-mir-4731-5p ; hsa-mir-210-5p ; hsa-mir-4313 ; hsa-mir-1233-3p ; hsa-mir-6506-5p ; hsa-mir-1225-3p ; hsa-mir-619-5p ; hsa-mir-324-3p ; hsa-mir-1913 ; hsa-mir-6752-3p ; hsa-mir-6810-3p ; hsa-mir-6801-3p ; hsa-mir-512-3p ; hsa-mir-6769a-3p ; hsa-mir-195-5p ; hsa-mir-16-5p ; hsa-mir-15b-5p ; hsa-mir-15a-5p
Nearest miRNA
hsa-let-7a-1/Upstream/1719120; hsa-mir-12126/Downstream/6652591;
Nearest TSS
ENST00000422679/Upstream/10429; ENST00000529385/Downstream/18933;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/41146, chr9-CpG: 69/Downstream/150156
Upstream sequence
accagatttctaagacttactacaaataaaacaatgtaaaagattttaagttttataattgcatattaaaatagtattttagctatattaggttaaataa
Downstream sequence
aatattattaaaattaatttcccttgtttttacttttttaatgtaatttaaaaaatttttaaattacatatgtggcttgtgtgtgtgatttgcattatgt
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate