Basic Information
VIS ID
TVIS44006755
Fusion event
HTLV-1-SLC44A1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
q31.1
Reference genome
GRCh37/hg19
Start
108140658/105378377 (Hg38)
End
108140658/105378377 (Hg38)
Orient
+
Location type
Intronic
Target gene
SLC44A1
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-130b-3p ; hsa-mir-124-3p ; hsa-mir-122-5p ; hsa-mir-19b-3p ; hsa-mir-545-5p ; hsa-mir-7161-3p ; hsa-mir-3156-5p ; hsa-mir-3185 ; hsa-mir-203a-3p ; hsa-mir-3646 ; hsa-mir-3941 ; hsa-mir-6865-3p ; hsa-mir-4789-3p ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-8485 ; hsa-mir-5000-3p ; hsa-mir-4436a ; hsa-mir-1197 ; hsa-mir-875-5p ; hsa-mir-4684-5p ; hsa-mir-4668-5p ; hsa-mir-1283 ; hsa-mir-3675-3p ; hsa-mir-4311 ; hsa-mir-6809-5p ; hsa-mir-5695 ; hsa-mir-6830-5p ; hsa-mir-651-3p ; hsa-mir-2681-5p ; hsa-mir-186-5p ; hsa-mir-3133 ; hsa-let-7a-2-3p ; hsa-let-7c-3p ; hsa-let-7g-3p ; hsa-mir-129-5p ; hsa-mir-4797-5p ; hsa-mir-493-5p
Nearest miRNA
hsa-let-7a-1/Upstream/7149160; hsa-mir-12126/Downstream/1222551;
Nearest TSS
ENST00000422679/Upstream/22460; ENST00000436716/Downstream/8311;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/132737, chr9-CpG: 73/Downstream/69427
Upstream sequence
GAAGGCAGTTTTGTATACCTCTTTTCACTTGGTGTTACATTATGAGCATTTCTTGTTTTCTTAACACTTTTCTAACTATGGTTATACAACTGTTGTGTCa
Downstream sequence
tttatttaatcaatcctcaggttttctgttttttacagttgagctgtgctcaattttttactaacctaaagcttgtatttgtgtgtaaatcttgcccaca
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate