Basic Information
VIS ID
TVIS44006768
Fusion event
HTLV-1-DOCK11 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chrX
Cytoband
q24
Reference genome
GRCh37/hg19
Start
117655298/118521335 (Hg38)
End
117655298/118521335 (Hg38)
Orient
+
Location type
Intronic
Target gene
DOCK11
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-92b-3p ; hsa-mir-99a-5p ; hsa-mir-107 ; hsa-mir-103a-3p ; hsa-mir-4786-5p ; hsa-mir-4468 ; hsa-mir-6849-3p ; hsa-mir-4293 ; hsa-mir-6838-5p ; hsa-mir-497-5p ; hsa-mir-424-5p ; hsa-mir-195-5p ; hsa-mir-16-5p ; hsa-mir-15b-5p ; hsa-mir-15a-5p ; hsa-mir-6771-3p ; hsa-mir-122-5p ; hsa-mir-143-5p ; hsa-mir-3689d ; hsa-mir-377-5p ; hsa-mir-4426 ; hsa-mir-4463 ; hsa-mir-4494 ; hsa-mir-4534 ; hsa-mir-455-3p ; hsa-mir-4647 ; hsa-mir-4662b ; hsa-mir-4695-3p ; hsa-mir-4802-5p ; hsa-mir-504-3p ; hsa-mir-566 ; hsa-mir-5693 ; hsa-mir-5698 ; hsa-mir-6086 ; hsa-mir-6499-3p ; hsa-mir-6516-5p ; hsa-mir-652-3p ; hsa-mir-6787-3p ; hsa-mir-6789-3p ; hsa-mir-6807-5p ; hsa-mir-6851-5p ; hsa-mir-7641 ; hsa-mir-8082
Nearest miRNA
hsa-let-7f-2/Upstream/134864; hsa-mir-105-1/Downstream/1125403;
Nearest TSS
ENST00000429181/Upstream/25426; ENST00000633080/Downstream/24776;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/24829, chrX-CpG: 108/Downstream/205916
Upstream sequence
tgggaaacttactcaacctttttaagtcccagtttctttgtttataaaataggagtgatggtgataatcatacctaccgcataaggtaagcatgaggcct
Downstream sequence
aaagggataatccatggtcaaccctttgcatagGCTAAGTGTTAGCTATTATTATTCATCAATTCACCTCCGTGTGTAGTTTTTGTATGAAGGGGGAACA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate