Basic Information
VIS ID
TVIS44006798
Fusion event
HTLV-1-ARLNC1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr16
Cytoband
q23.2
Reference genome
GRCh37/hg19
Start
80877807/80843910 (Hg38)
End
80877807/80843910 (Hg38)
Orient
+
Location type
ncRNA_intronic
Fragile sites / regions
FRA16D
Target gene
ARLNC1
Nearest miRNA
hsa-mir-1225/Upstream/3974891; hsa-mir-11401/Downstream/541108;
Nearest TSS
ENST00000527434/Upstream/8121; ENST00000568445/Downstream/26610;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/38947, chr16-CpG: 52/Downstream/88145
Upstream sequence
gcaacacaaaatgtagagaagcatgaaaaatcaaggaaaaggaggacagggtagggaaaaaaagaaatcaagaaaacatgacaccaccaaaagaacagaa
Downstream sequence
taaccaactccaaagataaggagatctgtaattgcctgaaaagatttcaaaataatttcttaagaaaactcaaagagctgtaaaaaaaaaaaaaaaaaaa
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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