Basic Information
VIS ID
TVIS44006810
Fusion event
HTLV-1-CTNNA2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
p12
Reference genome
GRCh37/hg19
Start
80822265/80595140 (Hg38)
End
80822265/80595140 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA2S
Target gene
CTNNA2
Nearest miRNA
hsa-mir-1285-2/Upstream/728557; hsa-mir-10b/Downstream/5188460;
Nearest TSS
ENST00000437798/Upstream/5801; ENST00000448431/Downstream/10493;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/272467, chr2-CpG: 93/Downstream/598940
Nearest cancer related gene
CTNNA2(TSG, No orient, 0)
Upstream sequence
tgcctttgggttttgatagggattacagtgaatctgtagatctctttcagtagtattgacatcttaatattaagtcttccaatccacatttattgaatga
Downstream sequence
ctttccatttatttttgtaatttcaacaatattttgtagttttcagcatgcaagtcttctgactccatggttaagcttattcctaaacattttatttttt
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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