Basic Information
VIS ID
TVIS44006813
Fusion event
HTLV-1-GIGYF2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q37.1
Reference genome
GRCh37/hg19
Start
233609573/232744863 (Hg38)
End
233609573/232744863 (Hg38)
Orient
+
Location type
Intronic
Target gene
GIGYF2
miRNAs that regulate target gene
hsa-mir-34a-5p ; hsa-mir-455-3p ; hsa-mir-505-3p ; hsa-mir-519e-5p ; hsa-mir-513b-5p ; hsa-mir-515-5p ; hsa-mir-5189-3p ; hsa-mir-5695 ; hsa-mir-519d-5p ; hsa-mir-454-5p ; hsa-mir-125b-2-3p ; hsa-mir-4457 ; hsa-mir-3667-5p
Nearest miRNA
hsa-mir-10b/Upstream/194290; hsa-mir-149/Downstream/4766068;
Nearest TSS
ENST00000437798/Upstream/41442; ENST00000473170/Downstream/19573;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/47026, chr2-CpG: 138/Downstream/131095
Upstream sequence
tgaagtgatccacactccttagcttcccaagtgttgggattacaagtgtgagctaacctgcaaccggtcAATTGTggtctttttagtaataaaaacctag
Downstream sequence
gtttgaatctttgttctgctgcccgtgactgtggacaagttgtttaacccttcagctttatttttatctgttatgtttgggttgttgtgaaggttaaatt
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate