Basic Information
VIS ID
TVIS44006814
Fusion event
HTLV-1-C20orf27 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr20
Cytoband
p13
Reference genome
GRCh37/hg19
Start
3747650/3767003 (Hg38)
End
3747650/3767003 (Hg38)
Orient
-
Location type
Intronic
Target gene
C20orf27
miRNAs that regulate target gene
hsa-mir-103a-3p ; hsa-mir-320a ; hsa-mir-6126 ; hsa-mir-486-3p ; hsa-mir-6721-5p ; hsa-mir-4763-3p ; hsa-mir-1207-5p ; hsa-mir-885-3p ; hsa-mir-6853-5p ; hsa-mir-2467-3p ; hsa-mir-7854-3p ; hsa-mir-423-5p ; hsa-mir-3184-5p ; hsa-mir-4493 ; hsa-mir-605-3p ; hsa-mir-4257 ; hsa-mir-4719 ; hsa-mir-6743-5p ; hsa-mir-4688 ; hsa-mir-6511a-5p ; hsa-mir-1910-3p ; hsa-mir-3714 ; hsa-mir-3646
Nearest miRNA
hsa-mir-1292/Upstream/1114161; hsa-mir-1-1/Downstream/150491;
Nearest TSS
ENST00000382410/Upstream/8325; ENST00000468979/Downstream/725;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/14854, chr20-CpG: 100/Downstream/663
Upstream sequence
TCTCAGTCCCTGCTTACTAATGGAAACACGGGTCCAGAACCTAAATCCAGTCCCTCCTCCTTCATACCACCGGGAGGGAGGTGCAGCCCAAGCCCCCGAG
Downstream sequence
GCCCCAAGGGTCCAGGTGTAGGACCCTTTATCCTCTCCGGCAGCCATCCCTGTGGGTGTGGCACCCCCGCCACACCCCATTCTTGTCATCTCAGGGGGAG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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