Basic Information
VIS ID
TVIS44006819
Fusion event
HTLV-1-NCAM2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr21
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
22813340/21441020 (Hg38)
End
22813340/21441020 (Hg38)
Orient
-
Location type
Intronic
Target gene
NCAM2
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-26b-5p ; hsa-mir-6885-3p ; hsa-mir-1273e ; hsa-mir-3591-3p ; hsa-mir-21-3p ; hsa-mir-1277-5p ; hsa-mir-3924 ; hsa-mir-190a-3p ; hsa-mir-223-5p ; hsa-mir-511-3p ; hsa-mir-5011-5p ; hsa-mir-3065-5p ; hsa-mir-3529-3p ; hsa-mir-5688 ; hsa-mir-495-3p ; hsa-mir-3658 ; hsa-mir-6505-5p ; hsa-mir-3653-3p ; hsa-mir-4790-3p ; hsa-mir-6507-5p ; hsa-mir-2116-5p ; hsa-mir-22-5p ; hsa-mir-26b-3p ; hsa-mir-3622a-5p ; hsa-mir-4423-3p ; hsa-mir-4652-3p ; hsa-mir-4677-5p ; hsa-mir-4778-5p ; hsa-mir-5582-5p ; hsa-mir-627-3p ; hsa-mir-6806-5p
Nearest miRNA
hsa-let-7c/Upstream/2754856; hsa-mir-155/Downstream/1638264;
Nearest TSS
ENST00000624081/Upstream/150943; ENST00000484983/Downstream/22721;
Nearest CpG islands
None/Target, chr21-CpG: 261/Upstream/442775, chr21-CpG: 28/Downstream/3920774
Upstream sequence
AAATATAAGTCAAGTTAACAATCAAACTCATTTGATTGACTCATTTAAATGACTCGAATTAGCAGGGTTTCAAATAAAAATTAATGAAATTCTTCATAAC
Downstream sequence
CCTGTAGTCTTCCAAATCAAAATTTTCAAACATACTTTTCTCTCTTGCTCATCATACTTCACTCTCAATTTGTAGATTTTTAAATTCTGGAAGTGTTTCT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate