Proximate region of VIS (GRCh38)VISEnhancerEnhancer/PromoterPromoterGene5645383356049073563286255621430656219049562449445624849356234251562371105624025456242838562199565622118756226655562268045622496556225024562432155624325756251453
Basic Information
VIS ID
TVIS44006830
Fusion event
HTLV-1-KIAA1211 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q12
Reference genome
GRCh37/hg19
Start
57117619/56251453 (Hg38)
End
57117619/56251453 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA4B
Target gene
KIAA1211
miRNAs that regulate target gene
hsa-mir-769-5p ; hsa-mir-27b-3p ; hsa-mir-203b-3p ; hsa-mir-7158-3p ; hsa-mir-664b-3p ; hsa-mir-579-3p ; hsa-mir-5696 ; hsa-mir-4635 ; hsa-mir-4729 ; hsa-mir-664a-3p ; hsa-mir-1264
Nearest miRNA
hsa-mir-12113/Upstream/3538706; hsa-mir-1243/Downstream/4671166;
Nearest TSS
ENST00000502981/Upstream/4950; ENST00000505410/Downstream/20951;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/201718, chr4-CpG: 137/Downstream/62606
Upstream sequence
CTCCTTGAAATTGATATTTGAAAGGCACTCAAAAAATATCAGGTGATGCGATTCAGCAGAGACGTGTCTGGTGTGTGCAGATTTTATTTCCTTTAGCCCA
Downstream sequence
GGCCAGAATTTTATATTGAAAGTGAAGCATATATGAAAAGTAAAGCATAATACTTTCTTAAAGTTCTACCCCAAATTATGAGTATTTAGGTTATACTCAA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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