Basic Information
VIS ID
TVIS44006847
Fusion event
HTLV-1-FBXO9 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
p12.1
Reference genome
GRCh37/hg19
Start
52927277/53062479 (Hg38)
End
52927277/53062479 (Hg38)
Orient
-
Location type
Intronic
Target gene
FBXO9
miRNAs that regulate target gene
hsa-mir-192-3p ; hsa-mir-1277-5p ; hsa-mir-587 ; hsa-mir-5011-5p ; hsa-mir-190a-3p ; hsa-mir-4789-5p ; hsa-mir-3941 ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-8485 ; hsa-mir-5189-3p ; hsa-mir-4753-3p ; hsa-mir-130b-5p ; hsa-mir-1283 ; hsa-mir-6769b-3p ; hsa-mir-4723-3p ; hsa-mir-3183 ; hsa-mir-6800-3p ; hsa-mir-4753-5p ; hsa-mir-6768-3p ; hsa-mir-4729
Nearest miRNA
hsa-mir-10398/Upstream/913438; hsa-mir-10524/Downstream/214514;
Nearest TSS
ENST00000381078/Upstream/677; ENST00000461222/Downstream/2519;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/414, chr6-CpG: 76/Downstream/2773
Nearby gene
ICK(-677) ;
Upstream sequence
TAGTCAGATATCCTCTACACAACAATCGTCCTCTGTAACTAGTTATAGGGAATCTGACACTAACACGTAATTTTATAACACATTGATTTATGTCATAAGT
Downstream sequence
GATATTGTAGACATTACCTTAAATCATCCTTATAAGGCTAGAGCGGTTTGAATAAAGAAGTTGCTTCCAGGTCCCTGATTTTAAATTTACATAATTGTTC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate