Basic Information
VIS ID
TVIS44006856
Fusion event
HTLV-1-DGKI integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q33
Reference genome
GRCh37/hg19
Start
137497306/137812560 (Hg38)
End
137497306/137812560 (Hg38)
Orient
-
Location type
Intronic
Target gene
DGKI
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-127-5p ; hsa-mir-7843-3p ; hsa-mir-4786-3p ; hsa-mir-4635 ; hsa-mir-7-2-3p ; hsa-mir-7-1-3p
Nearest miRNA
hsa-mir-10525/Upstream/909266; hsa-mir-10399/Downstream/311198;
Nearest TSS
ENST00000635602/Upstream/37570; ENST00000418554/Downstream/33976;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/647961, chr7-CpG: 117/Downstream/33819
Upstream sequence
TAGAGTCTTAGAGGACAGTAAGGTGCCAAGGCAGGATGACTGATAAAGAAACCCTGCCCTTTCAGGCGCAATTTTGAGGTCCTTATGCTGAGCCCCTAGC
Downstream sequence
ATCATCACTGTAACTAAAATTTGATATCTTAATGCATAAATggcagtattccaagccctttccatatattaattcatttaatcatcactcacaataaccc
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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