Basic Information
VIS ID
TVIS44006870
Fusion event
HTLV-1-ST3GAL3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p34.1
Reference genome
GRCh37/hg19
Start
44316725/43851053 (Hg38)
End
44316725/43851053 (Hg38)
Orient
+
Location type
Intronic
Target gene
ST3GAL3
Nearest miRNA
hsa-mir-12136/Upstream/12370; hsa-mir-101-1/Downstream/694440;
Nearest TSS
ENST00000473358/Upstream/12803; ENST00000647299/Downstream/28191;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/142961, chr1-CpG: 35/Downstream/82343
Upstream sequence
TGCGGACTTGGCAGCCTCTCAGGTTCTTGTGAGTGGTGGTGGCAGTGTTCAAATGGGGAGGGCACCACGCCAGCTGCCACCAGCCTGCTGATATGTGCCA
Downstream sequence
TGTCCACCATGAGATACACCCCATTCTCATCTGCAGTTTTTCTGCAGCGGGGCATAGTCCAGGTTTTAGGAGGAGCAGCTGGTTCCTGCACTGATCAGCT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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