Basic Information
VIS ID
TVIS44006876
Fusion event
HTLV-1-AMPD2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p13.3
Reference genome
GRCh37/hg19
Start
110170298/109627676 (Hg38)
End
110170298/109627676 (Hg38)
Orient
+
Location type
Intronic
Target gene
AMPD2
miRNAs that regulate target gene
hsa-mir-939-5p ; hsa-mir-484 ; hsa-mir-10a-5p ; hsa-mir-24-3p ; hsa-let-7e-5p ; hsa-let-7a-5p
Nearest miRNA
hsa-mir-101-1/Upstream/28709; hsa-mir-11399/Downstream/2834094;
Nearest TSS
ENST00000473358/Upstream/753; ENST00000529299/Downstream/98;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/7582, chr1-CpG: 16/Downstream/15663
Upstream sequence
CAGTTCTGCCCCAGACTCCCATCACCTGGTGTCTTGCCCTTCCTAGTTGCTGAGCCCTCGACTTCCCCGCAGTCTACTTCCCTCTTGGCAGCCTCCATCC
Downstream sequence
TTACCCTCCCACCTGCTCCCTCTGATCTGCTACCCAAGCCCTCCCCAGGTGCCTCCCTTCAGGGCCTAAGTCCCTGCCTTGTTCTCCTCATGCCCAGAAA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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