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Viral Integration Site DataBase
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TVIS44006877
Basic Information
VIS ID
TVIS44006877
Fusion event
HTLV-1-ARHGEF2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
q22
Reference genome
GRCh37/hg19
Start
155920399/155950608 (Hg38)
End
155920399/155950608 (Hg38)
Orient
-
Location type
Intronic
Target gene
ARHGEF2
miRNAs that regulate target gene
hsa-mir-335-5p
;
hsa-mir-96-5p
;
hsa-mir-877-3p
;
hsa-mir-744-5p
;
hsa-mir-423-3p
;
hsa-mir-320a
;
hsa-mir-4728-5p
;
hsa-mir-328-3p
;
hsa-mir-6734-5p
;
hsa-mir-1226-5p
;
hsa-mir-6834-5p
;
hsa-mir-3175
;
hsa-mir-8085
;
hsa-mir-6731-5p
;
hsa-mir-6851-3p
;
hsa-mir-6775-3p
;
hsa-mir-1291
;
hsa-mir-6799-3p
;
hsa-mir-3173-5p
;
hsa-mir-6086
;
hsa-mir-377-5p
;
hsa-mir-6738-5p
;
hsa-mir-5194
;
hsa-mir-1914-3p
;
hsa-mir-423-5p
;
hsa-mir-3184-5p
;
hsa-mir-4784
;
hsa-mir-3150b-3p
;
hsa-mir-7845-5p
;
hsa-mir-942-3p
;
hsa-mir-4475
;
hsa-mir-194-3p
Nearest miRNA
hsa-mir-101-1/Upstream/604163; hsa-mir-1182/Downstream/665;
Nearest TSS
ENST00000473358/Upstream/8898;
ENST00000610146/Downstream/1140;
Nearest CpG islands
None/Target,
chr1-CpG: 111/Upstream/16092
,
chr1-CpG: 22/Downstream/252
Nearest cancer related gene
ARHGEF2
(OG, No orient, 0)
Upstream sequence
CAGGTCAGGGACTGAGTAGTGTGAAGATTGGAGGTTCTGCTTGGCTGAAGGCAGCAGCTCTCCCCCCTGGGGCTCACCCATGAGTCCCCTTCAGGAGATC
Downstream sequence
CACCACCAACTGGCCTCTTTCAGCACCACGACCCGAGTTAATTTCCTCCACCCCTGCACCCATCTACATTTCTTTTCAGTTCTCCAACCAGTATCTCAAT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Sample Information
×
Sample name
ATL12
Sample type
Nontumor
Gender
Female
CpG Island Information
×
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