Basic Information
VIS ID
TVIS44006886
Fusion event
HTLV-1-DNAJC1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
p12.31
Reference genome
GRCh37/hg19
Start
22171882/21882953 (Hg38)
End
22171882/21882953 (Hg38)
Orient
-
Location type
Intronic
Target gene
DNAJC1
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-16-5p ; hsa-let-7b-5p
Nearest miRNA
hsa-mir-1265/Upstream/386312; hsa-mir-107/Downstream/2392732;
Nearest TSS
ENST00000439456/Upstream/22047; ENST00000564681/Downstream/120446;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/347472, chr10-CpG: 77/Downstream/120092
Upstream sequence
ATGGTATACATTTATTTTTCAATATTTTACAAAGGTGAAATATGATCTGGCAACATCAAGAGTAGTTATGAATCGATGGCCATCCATTGGGCTCTTTATT
Downstream sequence
AAATCCCATTTTAggcctaggagcagtggttcacggctctaatcccagcattttgggaggccaaggcaggtgcatcactggaggccaggagttcgagacc
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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