Basic Information
VIS ID
TVIS44006894
Fusion event
HTLV-1-VPS26A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
70928631/69168875 (Hg38)
End
70928631/69168875 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA10C
Target gene
VPS26A
miRNAs that regulate target gene
hsa-mir-373-3p ; hsa-mir-7-5p ; hsa-mir-21-5p ; hsa-mir-17-5p ; hsa-mir-20a-5p ; hsa-mir-93-5p ; hsa-mir-106b-5p ; hsa-mir-20b-5p ; hsa-mir-519d-3p
Nearest miRNA
hsa-mir-1265/Upstream/1765465; hsa-mir-107/Downstream/2621872;
Nearest TSS
ENST00000439456/Upstream/35977; ENST00000497022/Downstream/1159;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/44278, chr10-CpG: 38/Downstream/11265
Upstream sequence
GGAGAATAGAATCCTATGATAGATCCCTCCCCAATCATTCTGCAGTACTCCAGAATGAGCTATAATTTTTCAGGGCTTTTAGTTTTCTCTTACAAGTTCT
Downstream sequence
TTTGTTTTTGTTTTTTAATAAAAACAATACCTGCTGCTTATTTAGAAAAAAATAAGGCAATAAAGAACAAAGAATGAAGTAAAGGTCAGCAGAATTTCCA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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