VISDB - VIS Detail

Basic Information

VIS ID

TVIS44006952

Fusion event

HTLV-1-BCAS3 integration

Validated

No

Detection method

HTS

Data source

download(RID)

Sample type

Nontumor

Disease

Adult T-cell leukemia (ATL)

Quality evaluation

Normal

Reported year

2014

PubMed ID

24735963

Virus Sequence

Virus name

HTLV-1

Reference genome

Not given

Host Sequence

Chromosome

chr17

Cytoband

q23.2

Reference genome

GRCh37/hg19

Start

58949931/60872570 (Hg38)

End

58949931/60872570 (Hg38)

Orient

+

Location type

Intronic

Target gene

BCAS3

miRNAs that regulate target gene

hsa-mir-1278 ; hsa-mir-1285-3p ; hsa-mir-2861 ; hsa-mir-3187-5p ; hsa-mir-326 ; hsa-mir-330-5p ; hsa-mir-3664-5p ; hsa-mir-3667-3p ; hsa-mir-378g ; hsa-mir-4486 ; hsa-mir-4714-5p ; hsa-mir-514a-5p ; hsa-mir-5189-5p ; hsa-mir-612 ; hsa-mir-6734-3p ; hsa-mir-6860 ; hsa-mir-6883-3p

Nearest miRNA

hsa-mir-10226/Upstream/829465; hsa-mir-1250/Downstream/2071645;

Nearest TSS

ENST00000595228/Upstream/193112; ENST00000586705/Downstream/13813;

Nearest CpG islands

None/Target, chr17-CpG: 26/Upstream/194451, chr17-CpG: 720/Downstream/523129

Upstream sequence

tatctgtatgtatatatctgtatgtatatatacacacatacacaccccatatatatctgtatgtgtatatctgtatgtatatacacacacccccatatat

Downstream sequence

atctgtatgtatataCACACATGGACACACACCCCATATCTATTTTTATGTATATACACACATACACACACACCCCGatatctatctgtatgtatataca

Reference

Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.