Basic Information
VIS ID
TVIS44006957
Fusion event
HTLV-1-PIEZO2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr18
Cytoband
p11.21
Reference genome
GRCh37/hg19
Start
11066309/11066310 (Hg38)
End
11066309/11066310 (Hg38)
Orient
-
Location type
Intronic
Target gene
PIEZO2
Nearest miRNA
hsa-mir-3976/Upstream/306661; hsa-mir-1-2/Downstream/588575;
Nearest TSS
ENST00000575820/Upstream/172693; ENST00000591029/Downstream/82278;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/339641, chr18-CpG: 169/Downstream/81998
Upstream sequence
GGAATGCACATGCTGTGGGTGGGAAGAGAGAAGAGAGTGAGAAGATCATTAACAAAGGCAGGTTGACAAAACCAGGGGTGCATAACAAAAGATGGTCTCA
Downstream sequence
GATGTCACTGGATCAAACAGTGTCACTTCCTGAATAGATATGTCAATTAAACAGTAATAAATTAGGTATTTATTCTATGTTCATCACTGTGTTGAGCATG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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