Basic Information
VIS ID
TVIS44006961
Fusion event
HTLV-1-HAUS1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr18
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
43686685/46106719 (Hg38)
End
43686685/46106719 (Hg38)
Orient
+
Location type
Intronic
Target gene
HAUS1
miRNAs that regulate target gene
hsa-mir-92a-3p
Nearest miRNA
hsa-mir-1-2/Upstream/1136553; hsa-mir-122/Downstream/1273777;
Nearest TSS
ENST00000575820/Upstream/2297; ENST00000595199/Downstream/8349;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/1838, chr18-CpG: 175/Downstream/66618
Upstream sequence
TCAGATGTATGGTATTTGTTACATATGATATTTTGAATATAGTGCAGTTTATATTTGATTCTATTGCATATGTGCTTTTTTCCAGTTTTCTTTTAAAAGT
Downstream sequence
TAATATACAGCAGggccaggtgcagtggctcacgcctgtaatcccagcactttgggaggccaaggtgggcggatcacttgagaccaggagtttgagacaa
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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