Basic Information
VIS ID
TVIS44006962
Fusion event
HTLV-1-ZNF407 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr18
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
72716565/75004609 (Hg38)
End
72716565/75004609 (Hg38)
Orient
+
Location type
Intronic
Target gene
ZNF407
miRNAs that regulate target gene
hsa-mir-9-5p ; hsa-mir-218-5p
Nearest miRNA
hsa-mir-1-2/Upstream/2151227;
Nearest TSS
ENST00000575820/Upstream/127404; ENST00000582214/Downstream/55546;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/405881, chr18-CpG: 23/Downstream/83078
Upstream sequence
AAACGAGAGCGGCATTGGGTGCGCAGAGCCAGGGTCACTCAGCCTATCAAGCGAGTCTCTTGCTCGAGAGCCACCTGGTCCTGTCCGATTCATTCAATCA
Downstream sequence
GACCCATCGTTGAGAACTGGAATTTCACCAGGGATGGGCTGTTTTCCGGATTTTCCAGGGTTTATCACACTTAGCTAATACTTGGTGTGCAAAATGAAAG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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