Proximate region of VIS (GRCh38)VISEnhancerEnhancer/PromoterPromoterGene732691017321422273227237732022587321251373228006732332387321333673215768732020327320371373191133731925997321251373213203732183937321854273230117
Basic Information
VIS ID
TVIS44006972
Fusion event
HTLV-1-PRADC1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
p13.2
Reference genome
GRCh37/hg19
Start
73457245/73230117 (Hg38)
End
73457245/73230117 (Hg38)
Orient
-
Location type
Exonic
Fragile sites / regions
FRA2S ; FRA2E
Target gene
PRADC1
miRNAs that regulate target gene
hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-484
Nearest miRNA
hsa-mir-1285-2/Upstream/2977112; hsa-mir-10b/Downstream/1860695;
Nearest TSS
ENST00000437798/Upstream/4895; ENST00000464397/Downstream/3111;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/15428, chr2-CpG: 142/Downstream/2840
Upstream sequence
GTCCCAGCACTCAGGTGGGATGAGAGGGTCACTGCAGCTCAGTGAGGGGAAGGGGGAGGTTGAGGATCAGAGATCAGGGGCCTCCCTTAACTTACAAAGA
Downstream sequence
TACCACCAAAGTCCTTGGCAGGTGTGGCTGTGAAGATGTATCGAATGTCCCCAGGACTCAGCACTTGAAAGTACAAATAATCATGGATACGGAAGCCTGA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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