Basic Information
VIS ID
TVIS44006978
Fusion event
HTLV-1-LOC105373667 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
147002923/146245355 (Hg38)
End
147002923/146245355 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA2S ; FRA2K
Target gene
LOC105373667
Nearest miRNA
hsa-mir-128-1/Upstream/5658670; hsa-mir-10b/Downstream/3084923;
Nearest TSS
ENST00000437798/Upstream/330265; ENST00000450667/Downstream/592394;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/1720867, chr2-CpG: 49/Downstream/341878
Nearby gene
PABPC1P2(+341702) ;
Upstream sequence
GTACAAGTTTTAGGTTTGCATCCCCACTGTACTTCTGCAAAGGAAAGCCTCAAATTGCTGACTCCTTCAATAATGCAGATTGTTTACAAGTATGATATCC
Downstream sequence
AAAGAAAATAAACCTGTATAAATATAAGGAATATATTTCCTTTGACATTTTAATTGCCTTTATTTAAAAGTCATTTTGTACATTACTTTGTGGTATTGCA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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