Basic Information
VIS ID
TVIS44006985
Fusion event
HTLV-1-IGL integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr22
Cytoband
q11.22
Reference genome
GRCh37/hg19
Start
22564718/22210327 (Hg38)
End
22564718/22210327 (Hg38)
Orient
+
Location type
Intronic
Target gene
IGL
Nearest miRNA
hsa-mir-1286/Upstream/556942; hsa-let-7a-3/Downstream/612449;
Nearest TSS
ENST00000624155/Upstream/8664; ENST00000390287/Downstream/4467;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/92049, chr22-CpG: 21/Downstream/12937
Nearby gene
VPREB1(+34474) ;
Upstream sequence
cgcctccagggttcaggccaACTTACTGGCTTTTATATTTGGAATCACAACCTGAAAGGCTGCAGAACATGAAAGGAAGAAAACTCAGATTGCAGTGTTC
Downstream sequence
ATTCTCTTTTATATTATGAGTTTCCTGCAAGAGCTACATCTGTTATTATGCAAAAACAAACAGATAAGGAAACAAGAATTATCCAGCCTCAAGagtggaa
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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