Basic Information
VIS ID
TVIS44006989
Fusion event
HTLV-1-KAT2B integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
p24.3
Reference genome
GRCh37/hg19
Start
20095999/20054507 (Hg38)
End
20095999/20054507 (Hg38)
Orient
-
Location type
Intronic
Target gene
KAT2B
miRNAs that regulate target gene
hsa-mir-181a-5p ; hsa-mir-181b-5p ; hsa-mir-25-3p ; hsa-mir-32-5p ; hsa-mir-92a-3p ; hsa-mir-93-5p ; hsa-mir-106b-5p ; hsa-mir-19a-3p ; hsa-mir-19b-3p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-26b-5p ; hsa-mir-17-5p ; hsa-mir-92b-3p ; hsa-mir-142-3p ; hsa-mir-127-5p ; hsa-mir-539-5p
Nearest miRNA
hsa-mir-12127/Upstream/739576; hsa-let-7g/Downstream/83058;
Nearest TSS
ENST00000440867/Upstream/13809; ENST00000469085/Downstream/57087;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/13573, chr3-CpG: 62/Downstream/131290
Upstream sequence
gatgtgaAGGAGATGGATGCATTTATTTTGGAAAAAAGTGTGAATAATGTCTCTAATGGTCCACTTGGAACAATACATCACCTAATATCAGGAGGAGGTT
Downstream sequence
TAGGGTAATCTTGTCAGTAACCTCAGGGCAAGTTGTATGGGGTTGCTTCCATTAAATTCCATGCCATCCTAATCAGTCCCCATGCGTTGTGTACTCTTGG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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