Basic Information
VIS ID
TVIS44006999
Fusion event
HTLV-1-ATP6V1A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
q13.31
Reference genome
GRCh37/hg19
Start
113495414/113776567 (Hg38)
End
113495414/113776567 (Hg38)
Orient
+
Location type
Intronic
Target gene
ATP6V1A
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-26b-5p ; hsa-mir-361-5p ; hsa-mir-299-5p ; hsa-mir-6513-5p ; hsa-mir-887-5p ; hsa-mir-3913-5p ; hsa-mir-3122 ; hsa-mir-450a-1-3p ; hsa-mir-6780a-5p ; hsa-mir-6779-5p ; hsa-mir-3689c ; hsa-mir-3689b-3p ; hsa-mir-3689a-3p ; hsa-mir-30b-3p ; hsa-mir-1273h-5p ; hsa-mir-6788-5p ; hsa-mir-30c-2-3p ; hsa-mir-30c-1-3p ; hsa-mir-7977 ; hsa-mir-6740-5p ; hsa-mir-6799-5p ; hsa-mir-6883-5p ; hsa-mir-6785-5p ; hsa-mir-4728-5p ; hsa-mir-149-3p ; hsa-mir-7106-5p ; hsa-mir-24-3p ; hsa-mir-4284 ; hsa-mir-4530 ; hsa-mir-138-1-3p ; hsa-mir-513b-5p ; hsa-mir-6851-3p ; hsa-mir-6886-3p ; hsa-mir-6133 ; hsa-mir-6130 ; hsa-mir-6129 ; hsa-mir-6127 ; hsa-mir-4510 ; hsa-mir-4419a ; hsa-mir-5008-5p ; hsa-mir-5003-5p ; hsa-mir-4756-5p ; hsa-mir-4739 ; hsa-mir-1321 ; hsa-mir-6873-5p ; hsa-mir-4704-5p
Nearest miRNA
hsa-let-7g/Upstream/181625; hsa-mir-12124/Downstream/539908;
Nearest TSS
ENST00000440867/Upstream/29159; ENST00000461496/Downstream/24572;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/30255, chr3-CpG: 28/Downstream/62154
Upstream sequence
TCCCAAGGTGGTGTTTGCACCTCAATTGAGCATTTAAGTCATTTTGTTTTGCTATATAGCTATTTAAAGCTTCAAAAGCTCTGTAAACATATAATAAATG
Downstream sequence
GAATTCCATTGACATTCAAGCCTTACGTATTTCCAGAGCTTCTTCGACTTATCCTGCCTCCCCTACTTTAATTCTGTTAAAGTAGTTGAACACCATTCTT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate