Basic Information
VIS ID
TVIS44007004
Fusion event
HTLV-1-PIK3R4 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
130416433/130697589 (Hg38)
End
130416433/130697589 (Hg38)
Orient
-
Location type
Intronic
Target gene
PIK3R4
miRNAs that regulate target gene
hsa-mir-192-5p ; hsa-mir-1226-3p ; hsa-mir-503-5p ; hsa-mir-330-3p ; hsa-mir-26b-5p ; hsa-mir-26a-5p
Nearest miRNA
hsa-let-7g/Upstream/1425346; hsa-mir-1224/Downstream/1288266;
Nearest TSS
ENST00000440867/Upstream/6932; ENST00000509150/Downstream/26226;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/180230, chr3-CpG: 21/Downstream/49045
Upstream sequence
ttttttcaccccttctaccaactctgccttgtgattACATTTATAAGttgtgattgctctgagaatacaatgaacaccttaaaataatcaaattaatacc
Downstream sequence
aacttaatttcagtaatacataaaaactttgctctaatatgtctcttccctcctccctcatatgtataactattgtcatacaaattacatatctacatgt
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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