Basic Information
VIS ID
TVIS44007026
Fusion event
HTLV-1-MAML3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q31.1
Reference genome
GRCh37/hg19
Start
141008330/140087176 (Hg38)
End
141008330/140087176 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA4C
Target gene
MAML3
miRNAs that regulate target gene
hsa-mir-3682-3p ; hsa-mir-4424 ; hsa-mir-4679 ; hsa-mir-1273g-3p ; hsa-mir-1272 ; hsa-mir-1255b-2-3p ; hsa-mir-4477b ; hsa-mir-5684 ; hsa-mir-651-3p ; hsa-mir-548c-3p ; hsa-mir-452-3p ; hsa-mir-576-3p ; hsa-mir-539-3p ; hsa-mir-485-3p ; hsa-mir-101-3p ; hsa-mir-144-3p ; hsa-mir-499a-3p ; hsa-mir-499b-3p ; hsa-mir-505-3p ; hsa-mir-5696 ; hsa-mir-579-3p ; hsa-mir-664b-3p
Nearest miRNA
hsa-mir-12113/Upstream/14579869; hsa-mir-1305/Downstream/3256284;
Nearest TSS
ENST00000502981/Upstream/197124; ENST00000509184/Downstream/40839;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/226897, chr4-CpG: 20/Downstream/63193
Upstream sequence
ttgaacctgggaggtggaggttgcagtgagctgagatcgtgccattgcattccagcttgggcaagagtaagactccatctcaaaaaagaaaatacaaaaC
Downstream sequence
ATTCTCCTACCAATCCTTACTCAGAATTGAAATTTTCTATTTTTTGTGTGACTCTTTTACTAGTGATGTTCTCTTTTACTAGTAATCAGAGGGTCCATGC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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