Basic Information
VIS ID
TVIS44007030
Fusion event
HTLV-1-VEGFC integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q34.3
Reference genome
GRCh37/hg19
Start
177691019/176769865 (Hg38)
End
177691019/176769865 (Hg38)
Orient
-
Location type
Intronic
Target gene
VEGFC
miRNAs that regulate target gene
hsa-mir-1826 ; hsa-mir-128-3p ; hsa-mir-27b-3p ; hsa-mir-218-5p ; hsa-mir-4668-5p ; hsa-mir-3185 ; hsa-mir-3200-5p ; hsa-mir-4678 ; hsa-mir-577 ; hsa-mir-548m ; hsa-mir-6720-5p ; hsa-mir-6512-3p ; hsa-mir-196a-3p ; hsa-mir-6860 ; hsa-mir-661 ; hsa-mir-612 ; hsa-mir-5189-5p ; hsa-mir-3187-5p ; hsa-mir-1285-3p ; hsa-mir-766-3p ; hsa-mir-939-3p ; hsa-mir-6849-3p ; hsa-mir-6501-3p ; hsa-mir-508-5p ; hsa-mir-7703 ; hsa-mir-4252 ; hsa-mir-4793-3p ; hsa-mir-1273g-3p ; hsa-mir-101-3p ; hsa-mir-122-5p
Nearest miRNA
hsa-mir-12113/Upstream/2346001; hsa-mir-1305/Downstream/5399428;
Nearest TSS
ENST00000502981/Upstream/40273; ENST00000508790/Downstream/22862;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/449184, chr4-CpG: 100/Downstream/22224
Upstream sequence
tgactcagaaagcctgactcacagaattaaggtcatacagctcctgaggcccatcactaaattcaaatccagttctgatttggcagtttatgctgtttca
Downstream sequence
acctaccctgtactctcCAGTAATAACATAAAATAGAATGATTAAAGAAGGTTAATCTGAATTATCTGGGAATCAAATCTGGGTCCCTGAACTCCCTGAA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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