Basic Information
VIS ID
TVIS44007033
Fusion event
HTLV-1-FRG1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q35.2
Reference genome
GRCh37/hg19
Start
190863123/189941968 (Hg38)
End
190863123/189941968 (Hg38)
Orient
+
Location type
Intronic
Target gene
FRG1
miRNAs that regulate target gene
hsa-mir-30a-5p ; hsa-mir-1-3p
Nearest miRNA
hsa-mir-12113/Upstream/5003528;
Nearest TSS
ENST00000502981/Upstream/944; ENST00000507103/Downstream/18780;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/648, chr4-CpG: 73/Downstream/42110
Upstream sequence
TCCTGGTCTCCGTGATAAACAGAGGTTTTGATATTTTTAGGCGAGATAGAAAGTATCAAGGAGTGAGTTGAAGCCACTGGCCTTGAGAACCCTCTCGAGG
Downstream sequence
AGTCTGGCCTCATGAAGATGCCAGAATAAATGGCAGGTTTATCCTGAATGAATGTGAGATTTTTACTCTGTGAATTTCCTGGGAGGAGAGGAGAGTTATC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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