VISDB - VIS Detail

Basic Information

VIS ID

TVIS44007035

Fusion event

HTLV-1-OTULINL integration

Validated

Detection method

HTS

Data source

download(RID)

Sample type

Nontumor

Disease

Adult T-cell leukemia (ATL)

Quality evaluation

Normal

Reported year

2014

PubMed ID

24735963

Virus Sequence

Virus name

HTLV-1

Reference genome

Not given

Host Sequence

Chromosome

chr5

Cytoband

p15.2

Reference genome

GRCh37/hg19

Start

14605704/14605595 (Hg38)

End

14605704/14605595 (Hg38)

Orient

Location type

Intronic

Target gene

OTULINL

miRNAs that regulate target gene

hsa-let-7b-5p ; hsa-mir-124-3p ; hsa-mir-26b-5p ; hsa-mir-18a-3p ; hsa-mir-136-5p ; hsa-mir-6516-5p ; hsa-mir-550b-2-5p ; hsa-mir-6780a-5p ; hsa-mir-6779-5p ; hsa-mir-3689c ; hsa-mir-3689b-3p ; hsa-mir-3689a-3p ; hsa-mir-30b-3p ; hsa-mir-1273h-5p ; hsa-mir-455-3p ; hsa-mir-1227-3p ; hsa-mir-4451 ; hsa-mir-6799-5p ; hsa-mir-6883-5p ; hsa-mir-6785-5p ; hsa-mir-4728-5p ; hsa-mir-149-3p ; hsa-mir-7106-5p ; hsa-mir-4252 ; hsa-mir-6499-3p ; hsa-mir-6086 ; hsa-mir-377-5p ; hsa-mir-98-5p ; hsa-mir-4500 ; hsa-mir-4458 ; hsa-let-7i-5p ; hsa-let-7g-5p ; hsa-let-7f-5p ; hsa-let-7e-5p ; hsa-let-7d-5p ; hsa-let-7c-5p ; hsa-let-7a-5p ; hsa-mir-4537 ; hsa-mir-5186 ; hsa-mir-3192-5p ; hsa-mir-6831-5p ; hsa-mir-3927-3p ; hsa-mir-7851-3p ; hsa-mir-490-3p ; hsa-mir-127-5p ; hsa-mir-7843-3p ; hsa-mir-4635 ; hsa-mir-6814-5p ; hsa-mir-584-3p ; hsa-mir-382-5p

Nearest miRNA

hsa-mir-10397/Upstream/4127450; hsa-mir-103a-1/Downstream/220334;

Nearest TSS

ENST00000502646/Upstream/4630; ENST00000506258/Downstream/4743;

Nearest CpG islands

None/Target, chr5-CpG: 87/Upstream/23135, chr5-CpG: 129/Downstream/58543

Upstream sequence

tcattagttacgcaaatatctgcagccagcttgtatttctcctcagaaaatgagattttctttcctatagcattgtgaggctgcacattttctgaacttt

Downstream sequence

tacgctctctctttcaaaactgaatgcctttaacagcatccaagtcacttctgaatgctttgctgcttagaaatttctttcaccagatactctaaatcat

Reference

Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.