Basic Information
VIS ID
TVIS44007048
Fusion event
HTLV-1-ZNF292 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
q14.3
Reference genome
GRCh37/hg19
Start
87892012/87182294 (Hg38)
End
87892012/87182294 (Hg38)
Orient
-
Location type
Intronic
Target gene
ZNF292
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-21-5p ; hsa-mir-196a-3p ; hsa-mir-7153-5p ; hsa-mir-146b-5p ; hsa-mir-146a-5p ; hsa-mir-3925-5p ; hsa-mir-3120-3p ; hsa-mir-32-3p ; hsa-mir-1273g-3p ; hsa-mir-7703 ; hsa-mir-6720-5p ; hsa-mir-6512-3p ; hsa-mir-661 ; hsa-mir-6860 ; hsa-mir-612 ; hsa-mir-5189-5p ; hsa-mir-3187-5p ; hsa-mir-1285-3p ; hsa-mir-4793-3p ; hsa-mir-766-3p ; hsa-mir-939-3p ; hsa-mir-6849-3p ; hsa-mir-508-5p ; hsa-mir-200a-3p ; hsa-mir-141-3p ; hsa-mir-6873-3p ; hsa-mir-4795-3p ; hsa-mir-6817-3p ; hsa-mir-7110-3p ; hsa-mir-3675-3p ; hsa-mir-7151-5p ; hsa-mir-5003-3p
Nearest miRNA
hsa-mir-10398/Upstream/8642985; hsa-mir-1202/Downstream/3130448;
Nearest TSS
ENST00000381078/Upstream/26673; ENST00000485016/Downstream/31420;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/26235, chr6-CpG: 30/Downstream/140145
Nearest cancer related gene
ZNF292(TSG, No orient, 0)
Upstream sequence
ATGCAGGAGTAGCCCTTCAAAGTCATCGATCCCAAAAATGGTTGAGCTGAGAGAATGGAATAATTGTGTAAGTGTGTTTCCATAGTTAAAAGTCTATTAT
Downstream sequence
ATTGTAATTTAAACAAGAAACATCAAATGAGAACTTTTCAATTCTATTACTTTATTATCATGCTTGGTAGCTTAAAAAATTTCCACCTGGTTATTTCCTT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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