Basic Information
VIS ID
TVIS44007056
Fusion event
HTLV-1-ASNS integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q21.3
Reference genome
GRCh37/hg19
Start
97500930/97871618 (Hg38)
End
97500930/97871618 (Hg38)
Orient
-
Location type
Intronic
Target gene
ASNS
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-26b-5p ; hsa-mir-16-5p ; hsa-mir-615-3p ; hsa-mir-183-5p ; hsa-mir-23a-3p ; hsa-mir-17-5p
Nearest miRNA
hsa-mir-10525/Upstream/1651862; hsa-mir-10399/Downstream/92040;
Nearest TSS
ENST00000635602/Upstream/1641; ENST00000493372/Downstream/261;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/137912, chr7-CpG: 74/Downstream/253
Upstream sequence
TGTTAAATTATTAGTCAAGCGCCCAGGGCAATGGACAGTAAAGAAATAATGTAGGCCACGGGCCGAGATGAAAACTGTCCTTTTTATTTAAAGCTATAAC
Downstream sequence
AATCATCTGAAGCCAGCCCTGCAAAATGACAGCCATTGAAAAAGGCATGCTAGTTCTTTTGCCTTTTTCTGTACTTGGTCGCCTGTGTCCCTAAACAGAC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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