Basic Information
VIS ID
TVIS44007057
Fusion event
HTLV-1-CDHR3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
105637330/105996884 (Hg38)
End
105637330/105996884 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA7F
Target gene
CDHR3
miRNAs that regulate target gene
hsa-mir-331-3p
Nearest miRNA
hsa-mir-10525/Upstream/3525353; hsa-mir-10399/Downstream/8656461;
Nearest TSS
ENST00000635602/Upstream/33588; ENST00000466351/Downstream/4591;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/119367, chr7-CpG: 19/Downstream/12696
Upstream sequence
CCTGCCTGTTACTGGCTGCTCTAAAGTTTCTTCCTGCCATGGTGGATCCAGAAAAGTGATCCGGCTGTGTCTGGCAGCTCCTCTGTCCAGCAGAGGTGGG
Downstream sequence
AAGGGTAAATGCATCGGGTGGAGGGTAGTTTGTGGAAATGTGCCTGGCACTATCCCAGGCACAAAATGAAGATCTGAGCCTATTGTAGATGGGGATTTAG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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