Basic Information
VIS ID
TVIS44007065
Fusion event
HTLV-1-NECAB1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q21.3
Reference genome
GRCh37/hg19
Start
91852859/90840631 (Hg38)
End
91852859/90840631 (Hg38)
Orient
+
Location type
Intronic
Target gene
NECAB1
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-3941 ; hsa-mir-223-5p ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-8485 ; hsa-mir-297 ; hsa-mir-567 ; hsa-let-7c-3p ; hsa-mir-4719 ; hsa-mir-5582-5p ; hsa-mir-4698 ; hsa-mir-8063 ; hsa-mir-3074-3p ; hsa-mir-338-5p ; hsa-mir-1277-5p ; hsa-mir-4282 ; hsa-mir-6883-3p ; hsa-mir-6505-3p ; hsa-mir-617
Nearest miRNA
hsa-mir-12123/Upstream/10599158; hsa-mir-10400/Downstream/364854;
Nearest TSS
ENST00000518652/Upstream/48821; ENST00000522820/Downstream/18609;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/48718, chr8-CpG: 78/Downstream/144371
Upstream sequence
CTGTTTCTGAAGGCCCTGGCCGAGCAAATTTTTTATTGCTTTACTATCCCTCAATATTAAGTGGAGCTAATAATATTTTCTGGCAAGAAAATTGTAAAAA
Downstream sequence
CGTATGAGCAAATTTTTAAAAGCAGTGTAGACTGCTAGCCAGGGGAGGTGATATGTCAATATATGAGGTTTGTTTGACTGCGGTCTTAGAGTGCAGAACC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate