Basic Information
VIS ID
TVIS44007067
Fusion event
HTLV-1-chr8 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
105822144/104809916 (Hg38)
End
105822144/104809916 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA8A
Nearest miRNA
hsa-mir-12123/Upstream/325451; hsa-mir-10400/Downstream/7833577;
Nearest TSS
ENST00000518652/Upstream/106197; ENST00000522160/Downstream/378690;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/220440, chr8-CpG: 136/Downstream/508361
Nearby gene
LRP12(-220892) ;
Upstream sequence
tagagatggggtctcactatgttgctcaggctggattggaaatcctgaattcaaggaatcttactgcctcagccttttgaggagctgggactacaggACT
Downstream sequence
GCCTTATGGTCCCCTGGCAGAGACCTAGATTCTTGTCTTCATGATGCTAACACCTGGCCAGATGGACCAGACTTGTTTTTTATAGAGCAATGATGTTAGT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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